Product Data Sheet
PRMT5-IN-1
Catalog No. A26809
PRMT5-IN-1 is a selective inhibitor of protein arginine methyltransferase 5 (PRMT5), exhibiting an IC50 of 11 nM for the PRMT5/MEP50 complex. This hemiaminal compound can be metabolized to aldehydes, allowing it to form covalent adducts with C449 under physiological conditions. PRMT5-IN-1 is valuable for investigating the role of PRMT5 in various biological processes, including gene regulation and oncogenesis, making it a useful tool for cancer research and other studies involving protein methylation.
Chemical Information
| Catalog Num | A26809 |
|---|---|
| M. Wt | 418.83 |
| Formula | C19H19ClN4O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2366149-83-7 |
| Synonyms | |
| SMILES | O[C@@H]1[C@@H]([C@@H](C2=CC=C(Cl)C=C2)O)O[C@@H](N3C=CC4=C3N=CN5C4=NCC5O)[C@@H]1O |
Biological Activity
| Description | PRMT5-IN-1 is a selective inhibitor of protein arginine methyltransferase 5 (PRMT5), exhibiting an IC50 of 11 nM for the PRMT5/MEP50 complex. This hemiaminal compound can be metabolized to aldehydes, allowing it to form covalent adducts with C449 under physiological conditions. PRMT5-IN-1 is valuable for investigating the role of PRMT5 in various biological processes, including gene regulation and oncogenesis, making it a useful tool for cancer research and other studies involving protein methylation. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
