Product Data Sheet
MS33
Catalog No. A26817
MS33 is a potent WDR5 degrader that functions through E3 ligase VHL-mediated degradation. It exhibits binding affinities of 870 nM for VCB and 120 nM for WDR5, effectively targeting this protein for proteasomal degradation. MS33 is primarily utilized in research related to acute myeloid leukemia, aiding in the understanding of WDR5's role in cancer biology.
Chemical Information
| Catalog Num | A26817 |
|---|---|
| M. Wt | 1208.48 |
| Formula | C64H84F3N11O7S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2407449-11-8 |
| Synonyms | |
| SMILES | CN(CC1)CCN1C(C(NC(C2=CNC(C=C2C(F)(F)F)=O)=O)=C3)=CC=C3C4=CC(CN5CCN(CCNC(CCCCCCCCCC(N[C@@H](C(C)(C)C)C(N6C[C@H](O)C[C@H]6C(NCC7=CC=C(C8=C(C)N=CS8)C=C7)=O)=O)=O)=O)CC5)=CC=C4 |
Biological Activity
| Description | MS33 is a potent WDR5 degrader that functions through E3 ligase VHL-mediated degradation. It exhibits binding affinities of 870 nM for VCB and 120 nM for WDR5, effectively targeting this protein for proteasomal degradation. MS33 is primarily utilized in research related to acute myeloid leukemia, aiding in the understanding of WDR5's role in cancer biology. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
