Product Data Sheet
Lapatinib-d4 tosylate
Catalog No. A26891
Lapatinib-d4 tosylate is a deuterated form of Lapatinib, a highly effective inhibitor targeting the tyrosine kinase domains of ErbB-2 and EGFR. It demonstrates potent biological activity with IC50 values of 10.2 nM and 9.8 nM against purified EGFR and ErbB-2, respectively. This stable isotope-labeled compound is valuable in pharmacokinetic studies and can facilitate research in cancer biology, particularly in the context of targeted therapies for breast cancer.
Chemical Information
| Catalog Num | A26891 |
|---|---|
| M. Wt | 757.28 |
| Formula | C36H30D4ClFN4O7S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2749856-05-9 |
| Synonyms | GW572016-d4 tosylate; GW2016-d4 tosylate |
| SMILES | O=S(O)(C1=CC=C(C=C1)C)=O.CS(C([2H])([2H])C([2H])([2H])NCC2=CC=C(O2)C3=CC(C(NC4=CC(Cl)=C(C=C4)OCC5=CC(F)=CC=C5)=NC=N6)=C6C=C3)(=O)=O |
Biological Activity
| Description | Lapatinib-d4 tosylate is a deuterated form of Lapatinib, a highly effective inhibitor targeting the tyrosine kinase domains of ErbB-2 and EGFR. It demonstrates potent biological activity with IC50 values of 10.2 nM and 9.8 nM against purified EGFR and ErbB-2, respectively. This stable isotope-labeled compound is valuable in pharmacokinetic studies and can facilitate research in cancer biology, particularly in the context of targeted therapies for breast cancer. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
