Product Data Sheet
Rosiglitazone-d3
Catalog No. A26902
Rosiglitazone-d3 is a deuterium-labeled derivative of Rosiglitazone, a selective and orally active agonist of the peroxisome proliferator-activated receptor gamma (PPARγ). It exhibits EC50 values of 30 nM, 100 nM, and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively, with a binding affinity (Kd) of approximately 40 nM. In addition to its PPARγ activity, Rosiglitazone also activates TRPC5 with an EC50 of around 30 μM and inhibits TRPM3, making it a valuable tool for investigating metabolic and cardiovascular diseases.
Chemical Information
| Catalog Num | A26902 |
|---|---|
| M. Wt | 360.45 |
| Formula | C18H16D3N3O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1132641-22-5 |
| Synonyms | |
| SMILES | O=C(N1)C(CC2=CC=C(OCCN(C3=NC=CC=C3)C([2H])([2H])[2H])C=C2)SC1=O |
Biological Activity
| Description | Rosiglitazone-d3 is a deuterium-labeled derivative of Rosiglitazone, a selective and orally active agonist of the peroxisome proliferator-activated receptor gamma (PPARγ). It exhibits EC50 values of 30 nM, 100 nM, and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively, with a binding affinity (Kd) of approximately 40 nM. In addition to its PPARγ activity, Rosiglitazone also activates TRPC5 with an EC50 of around 30 μM and inhibits TRPM3, making it a valuable tool for investigating metabolic and cardiovascular diseases. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
