Product Data Sheet
Ferroptosis inducer-8
Catalog No. A26923
Ferroptosis inducer-8 is a potent ferroptosis inducer that selectively targets other cell death pathways. It functions by modulating the expression of ACSL4, GPX4, and FTH1, thereby disrupting iron homeostasis and impairing the GSH/GPX4 antioxidant defense system. This mechanism facilitates lipid peroxidation and promotes reactive oxygen species (ROS) production. Ferroptosis inducer-8 has demonstrated efficacy in inhibiting tumor growth, making it a valuable tool for research in triple-negative breast cancer (TNBC) and other malignancies.
Chemical Information
| Catalog Num | A26923 |
|---|---|
| M. Wt | 486.34 |
| Formula | C22H25Cl2NO7 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3097194-74-3 |
| Synonyms | |
| SMILES | O=C(OC)C1=CO[C@@H](OC)[C@]2([H])C(CN(C3=CC(OC)=C(Cl)C(OC)=C3)C(CCl)=O)=CC[C@@]21[H] |
Biological Activity
| Description | Ferroptosis inducer-8 is a potent ferroptosis inducer that selectively targets other cell death pathways. It functions by modulating the expression of ACSL4, GPX4, and FTH1, thereby disrupting iron homeostasis and impairing the GSH/GPX4 antioxidant defense system. This mechanism facilitates lipid peroxidation and promotes reactive oxygen species (ROS) production. Ferroptosis inducer-8 has demonstrated efficacy in inhibiting tumor growth, making it a valuable tool for research in triple-negative breast cancer (TNBC) and other malignancies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
