Product Data Sheet
BG11
Catalog No. A26929
BG11 is a potent ferroptosis inducer that promotes the accumulation of Fe2+ ions and intracellular lipid peroxides, leading to ferroptotic cell death. It modulates the expression of apoptotic regulators such as Bax and Bcl-2, facilitating apoptosis in MDA-MB-231 breast cancer cells. Furthermore, BG11 causes G0/G1 and S phase cell cycle arrest, significantly inhibiting the proliferation, migration, and invasion of triple-negative breast cancer (TNBC) cells, with IC50 values of 0.49 μM for MDA-MB-231 and 0.52 μM for BT549. In preclinical mouse models, BG11 demonstrates notable antitumor efficacy.
Chemical Information
| Catalog Num | A26929 |
|---|---|
| M. Wt | 559.51 |
| Formula | C26H28Cl2N6O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3065877-52-0 |
| Synonyms | |
| SMILES | CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@H](C4=NN=C(N42)C)CC(NC5CCN(CC5)C(CCl)=O)=O |
Biological Activity
| Description | BG11 is a potent ferroptosis inducer that promotes the accumulation of Fe2+ ions and intracellular lipid peroxides, leading to ferroptotic cell death. It modulates the expression of apoptotic regulators such as Bax and Bcl-2, facilitating apoptosis in MDA-MB-231 breast cancer cells. Furthermore, BG11 causes G0/G1 and S phase cell cycle arrest, significantly inhibiting the proliferation, migration, and invasion of triple-negative breast cancer (TNBC) cells, with IC50 values of 0.49 μM for MDA-MB-231 and 0.52 μM for BT549. In preclinical mouse models, BG11 demonstrates notable antitumor efficacy. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
