Product Data Sheet
Lapatinib-13C215N
Catalog No. A26949
Lapatinib-13C215N is a stable isotope-labeled variant of Lapatinib, specifically featuring 13C and 15N isotopes. This compound acts as a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains, displaying IC50 values of 10.2 nM and 9.8 nM, respectively, against purified targets. It is valuable for research applications in understanding signaling pathways involved in cancer and for quantitative analysis in pharmacokinetic studies.
Chemical Information
| Catalog Num | A26949 |
|---|---|
| M. Wt | 756.24 |
| Formula | C3413C2H34ClFN315NO7S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1246819-08-8 |
| Synonyms | |
| SMILES | CC1=CC=C(C=C1)S(=O)(O)=O.FC2=CC(COC3=CC=C(NC4=NC=NC5=CC=C(C=C54)C6=CC=C(O6)C[15NH][13CH2][13CH2]S(C)(=O)=O)C=C3Cl)=CC=C2 |
Biological Activity
| Description | Lapatinib-13C215N is a stable isotope-labeled variant of Lapatinib, specifically featuring 13C and 15N isotopes. This compound acts as a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains, displaying IC50 values of 10.2 nM and 9.8 nM, respectively, against purified targets. It is valuable for research applications in understanding signaling pathways involved in cancer and for quantitative analysis in pharmacokinetic studies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
