Product Data Sheet
Anticancer agent 199
Catalog No. A26950
Anticancer agent 199 is an apoptosis and ferroptosis inducer targeting multiple signaling pathways in triple negative breast cancer (TNBC) cells. It promotes cell death through the mitochondrial pathway by inhibiting EGFR, AKT, and MAPK signaling, while simultaneously down-regulating LCN2 to induce ferroptosis. This compound effectively reduces TNBC cell viability and migration, and induces S phase cell cycle arrest, making it a valuable tool for research on cancer therapeutics. Anticancer agent 199 is a derivative of the cyclin-dependent kinase inhibitor Rocovitine.
Chemical Information
| Catalog Num | A26950 |
|---|---|
| M. Wt | 556.12 |
| Formula | C29H39ClFN7O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2422001-24-7 |
| Synonyms | |
| SMILES | OCCN1CCC(CC1)C2CCN(CC2)C3=NC4=C(C(NCC5=CC=C(C(F)=C5)Cl)=N3)N=CN4C6CCCC6 |
Biological Activity
| Description | Anticancer agent 199 is an apoptosis and ferroptosis inducer targeting multiple signaling pathways in triple negative breast cancer (TNBC) cells. It promotes cell death through the mitochondrial pathway by inhibiting EGFR, AKT, and MAPK signaling, while simultaneously down-regulating LCN2 to induce ferroptosis. This compound effectively reduces TNBC cell viability and migration, and induces S phase cell cycle arrest, making it a valuable tool for research on cancer therapeutics. Anticancer agent 199 is a derivative of the cyclin-dependent kinase inhibitor Rocovitine. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
