Product Data Sheet
2-Acetamidophenol
Catalog No. A26980
2-Acetamidophenol, an ortho-regioisomer of Paracetamol, serves as a ferroptosis regulator, primarily influencing glutathione metabolic pathways. This compound exhibits anti-atherosclerotic properties, effectively reducing total cholesterol and triglyceride levels in zebrafish hyperlipidemia models with IC50 values of 30 μM and 40 μM, respectively. Additionally, 2-Acetamidophenol promotes the expression of genes associated with glutathione synthesis and iron ion transport, mitigates intracellular reactive oxygen species and ferrous ion accumulation, and enhances glutathione peroxidase GPX4 activity, consequently inhibiting macrophage phagocytosis of oxidized low-density lipoprotein and foam cell development.
Chemical Information
| Catalog Num | A26980 |
|---|---|
| M. Wt | 151.16 |
| Formula | C8H9NO2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 614-80-2 |
| Synonyms | Orthocetamol |
| SMILES | OC1=C(NC(C)=O)C=CC=C1 |
Biological Activity
| Description | 2-Acetamidophenol, an ortho-regioisomer of Paracetamol, serves as a ferroptosis regulator, primarily influencing glutathione metabolic pathways. This compound exhibits anti-atherosclerotic properties, effectively reducing total cholesterol and triglyceride levels in zebrafish hyperlipidemia models with IC50 values of 30 μM and 40 μM, respectively. Additionally, 2-Acetamidophenol promotes the expression of genes associated with glutathione synthesis and iron ion transport, mitigates intracellular reactive oxygen species and ferrous ion accumulation, and enhances glutathione peroxidase GPX4 activity, consequently inhibiting macrophage phagocytosis of oxidized low-density lipoprotein and foam cell development. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
