Product Data Sheet
Sorafenib-13C,d3
Catalog No. A27007
Sorafenib-13C,d3 is a stable isotope-labeled derivative of Sorafenib, a potent and orally bioavailable inhibitor of the mitogen-activated protein kinase (MAPK) pathway. Sorafenib exhibits strong biological activity, with IC50 values of 6 nM and 20 nM for Raf-1 and B-Raf, respectively, in addition to notable inhibition of multiple kinases such as VEGFR2 and PDGFRβ. This compound promotes autophagy and apoptosis and is recognized for its anti-tumor properties, serving as a valuable tool in cancer research and therapeutic studies exploring ferroptosis mechanisms.
Chemical Information
| Catalog Num | A27007 |
|---|---|
| M. Wt | 468.84 |
| Formula | C2013CH13D3ClF3N4O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1210608-86-8 |
| Synonyms | Bay 43-9006-13C,d3 |
| SMILES | O=C(NC(C=C1)=CC=C1OC2=CC(C(N[13C]([2H])([2H])[2H])=O)=NC=C2)NC3=CC=C(Cl)C(C(F)(F)F)=C3 |
Biological Activity
| Description | Sorafenib-13C,d3 is a stable isotope-labeled derivative of Sorafenib, a potent and orally bioavailable inhibitor of the mitogen-activated protein kinase (MAPK) pathway. Sorafenib exhibits strong biological activity, with IC50 values of 6 nM and 20 nM for Raf-1 and B-Raf, respectively, in addition to notable inhibition of multiple kinases such as VEGFR2 and PDGFRβ. This compound promotes autophagy and apoptosis and is recognized for its anti-tumor properties, serving as a valuable tool in cancer research and therapeutic studies exploring ferroptosis mechanisms. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
