Product Data Sheet
2-Acetamidophenol-d3
Catalog No. A27018
2-Acetamidophenol-d3 is a deuterium-labeled derivative of 2-Acetamidophenol, primarily utilized as a stable isotope. This compound influences ferroptosis and glutathione metabolism pathways, demonstrating anti-atherosclerotic properties. In zebrafish models of hyperlipidemia, it effectively reduces total cholesterol and triglyceride levels with IC50 values of 30 μM and 40 μM, respectively. Additionally, 2-Acetamidophenol-d3 enhances the expression of glutathione synthesis-related genes and mitigates the accumulation of reactive oxygen species, ultimately inhibiting the formation of foam cells through reduced macrophage uptake of oxidized low-density lipoprotein.
Chemical Information
| Catalog Num | A27018 |
|---|---|
| M. Wt | 154.18 |
| Formula | C8H6D3NO2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 122258-87-1 |
| Synonyms | Orthocetamol-d3 |
| SMILES | OC1=C(NC(C([2H])([2H])[2H])=O)C=CC=C1 |
Biological Activity
| Description | 2-Acetamidophenol-d3 is a deuterium-labeled derivative of 2-Acetamidophenol, primarily utilized as a stable isotope. This compound influences ferroptosis and glutathione metabolism pathways, demonstrating anti-atherosclerotic properties. In zebrafish models of hyperlipidemia, it effectively reduces total cholesterol and triglyceride levels with IC50 values of 30 μM and 40 μM, respectively. Additionally, 2-Acetamidophenol-d3 enhances the expression of glutathione synthesis-related genes and mitigates the accumulation of reactive oxygen species, ultimately inhibiting the formation of foam cells through reduced macrophage uptake of oxidized low-density lipoprotein. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
