Product Data Sheet
Angelic acid
Catalog No. A27075
Angelic acid is a ferroptosis inducer that targets NRF2 degradation. By binding to the NRF2 protein, it facilitates its ubiquitination and subsequent proteasomal degradation, thereby mitigating the protective effects of NRF2 against oxidative stress and promoting lipid peroxidation. This process leads to the induction of ferroptosis in tumor cells, evidenced by increased intracellular reactive oxygen species (ROS) and upregulation of ferroptosis-related markers such as CHAC1 and PTGS2. Additionally, Angelic acid exhibits the ability to scavenge UVA-induced ROS, inhibiting skin fibroblast senescence and extracellular matrix degradation, and promotes wound healing through its sedative properties.
Chemical Information
| Catalog Num | A27075 |
|---|---|
| M. Wt | 100.12 |
| Formula | C5H8O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 565-63-9 |
| Synonyms | |
| SMILES | C/C=C(C)\C(O)=O |
Biological Activity
| Description | Angelic acid is a ferroptosis inducer that targets NRF2 degradation. By binding to the NRF2 protein, it facilitates its ubiquitination and subsequent proteasomal degradation, thereby mitigating the protective effects of NRF2 against oxidative stress and promoting lipid peroxidation. This process leads to the induction of ferroptosis in tumor cells, evidenced by increased intracellular reactive oxygen species (ROS) and upregulation of ferroptosis-related markers such as CHAC1 and PTGS2. Additionally, Angelic acid exhibits the ability to scavenge UVA-induced ROS, inhibiting skin fibroblast senescence and extracellular matrix degradation, and promotes wound healing through its sedative properties. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
