Product Data Sheet
RWJ-49815
Catalog No. A27285
RWJ-49815 is a potent inhibitor of histidine kinases, exhibiting an IC50 value of 1.6 µM. It effectively inhibits the autophosphorylation activity of kinase A within the KinA-Spo0F two-component signaling system in vitro. This compound demonstrates significant antimicrobial activity against resistant bacterial strains, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and penicillin-resistant Streptococcus pneumoniae. Additionally, RWJ-49815 shows inhibitory effects on fungal species such as Saccharomyces cerevisiae and Candida albicans, making it a valuable tool for studying kinase-mediated processes and developing antimicrobial strategies.
Chemical Information
| Catalog Num | A27285 |
|---|---|
| M. Wt | 449.59 |
| Formula | C30H31N3O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 193282-45-0 |
| Synonyms | |
| SMILES | NC(NCCC1=CC=C(OCCC(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C=C1)=N |
Biological Activity
| Description | RWJ-49815 is a potent inhibitor of histidine kinases, exhibiting an IC50 value of 1.6 µM. It effectively inhibits the autophosphorylation activity of kinase A within the KinA-Spo0F two-component signaling system in vitro. This compound demonstrates significant antimicrobial activity against resistant bacterial strains, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and penicillin-resistant Streptococcus pneumoniae. Additionally, RWJ-49815 shows inhibitory effects on fungal species such as Saccharomyces cerevisiae and Candida albicans, making it a valuable tool for studying kinase-mediated processes and developing antimicrobial strategies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
