Product Data Sheet
NSC145366 monohydrochloride
Catalog No. A27407
NSC145366 monohydrochloride is an inhibitor of the Hsp90 chaperone protein, specifically targeting its C-terminal domain. By directly interacting with Hsp90, it effectively disrupts its chaperone activity, leading to a significant reduction in cellular growth. This compound has been shown to strongly inhibit the proliferation of Saccharomyces cerevisiae strains, specifically cog7Δ and cog8Δ, making it a valuable tool for research into protein homeostasis and cellular stress response pathways.
Chemical Information
| Catalog Num | A27407 |
|---|---|
| M. Wt | 635.36 |
| Formula | C37H63ClN2O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1052515-37-3 |
| Synonyms | |
| SMILES | OC(CNC(C)(CC(C)(C)C)C)COC1=CC=C(C(C)(C)C2=CC=C(C=C2)OCC(CNC(C)(CC(C)(C)C)C)O)C=C1.Cl |
Biological Activity
| Description | NSC145366 monohydrochloride is an inhibitor of the Hsp90 chaperone protein, specifically targeting its C-terminal domain. By directly interacting with Hsp90, it effectively disrupts its chaperone activity, leading to a significant reduction in cellular growth. This compound has been shown to strongly inhibit the proliferation of Saccharomyces cerevisiae strains, specifically cog7Δ and cog8Δ, making it a valuable tool for research into protein homeostasis and cellular stress response pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
