Product Data Sheet
Antifungal agent 22
Catalog No. A27651
Antifungal Agent 22 (compound D16) is an orally active antifungal agent targeting cryptococcal meningitis, exhibiting a potent IC50 of 0.5 μg/mL. This compound effectively penetrates the blood-brain barrier and exerts its antifungal activity by compromising the integrity of fungal cell membranes in Cryptococcus neoformans H99. Antifungal Agent 22 demonstrates selective anti-Cryptococcus efficacy, characterized by good metabolic stability and low cytotoxicity, making it a promising candidate for therapeutic applications in fungal infections.
Chemical Information
| Catalog Num | A27651 |
|---|---|
| M. Wt | 446.86 |
| Formula | C21H26Cl3NOS |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2640054-39-1 |
| Synonyms | |
| SMILES | ClC1=CC(C2C3=C(C(CC2)NCCC4CCOCC4)C=CS3)=CC=C1Cl.[H]Cl |
Biological Activity
| Description | Antifungal Agent 22 (compound D16) is an orally active antifungal agent targeting cryptococcal meningitis, exhibiting a potent IC50 of 0.5 μg/mL. This compound effectively penetrates the blood-brain barrier and exerts its antifungal activity by compromising the integrity of fungal cell membranes in Cryptococcus neoformans H99. Antifungal Agent 22 demonstrates selective anti-Cryptococcus efficacy, characterized by good metabolic stability and low cytotoxicity, making it a promising candidate for therapeutic applications in fungal infections. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
