Product Data Sheet

(Rac)-NPD6433

Catalog No. A27957

main product photo
(Rac)-NPD6433 is a Fas1 inhibitor targeting the enoyl reductase domain of fatty acid synthase 1. As a triazenyl indole, it demonstrates broad-spectrum antifungal activity against various screening fungal strains. By covalently inhibiting flavin mononucleotide-dependent NADPH-oxidation activity, (Rac)-NPD6433 effectively disrupts essential fatty acid biosynthesis, making it a valuable tool for research in fungal metabolism and potential therapeutic applications.
Chemical Information
Catalog NumA27957
M. Wt391.42
FormulaC21H21N5O3
Purity>98%
Storageat -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
CAS No.895908-81-3
Synonyms
SMILESO=C(C1=C(/N=N/N2CC3C4=CC=CC(N4CC(C3)C2)=O)C5=C(C=CC=C5)N1)OC
Biological Activity
Description(Rac)-NPD6433 is a Fas1 inhibitor targeting the enoyl reductase domain of fatty acid synthase 1. As a triazenyl indole, it demonstrates broad-spectrum antifungal activity against various screening fungal strains. By covalently inhibiting flavin mononucleotide-dependent NADPH-oxidation activity, (Rac)-NPD6433 effectively disrupts essential fatty acid biosynthesis, making it a valuable tool for research in fungal metabolism and potential therapeutic applications.
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