Product Data Sheet
L685818
Catalog No. A28078
L685818 is a specific immunophilin ligand that exhibits antifungal activity against Cryptococcus neoformans. In addition to its antifungal properties, L685818 demonstrates neuroregenerative effects by safeguarding dopaminergic neurons from toxicity associated with MPP+ and 6-OHDA. The compound effectively reduces the loss of tyrosine hydroxylase (TH) and promotes neuronal process regeneration, making it a valuable tool for research in neurodegenerative disease models and fungal infections.
Chemical Information
| Catalog Num | A28078 |
|---|---|
| M. Wt | 808.01 |
| Formula | C43H69NO13 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 143839-74-1 |
| Synonyms | |
| SMILES | O=C([C@@](CCCC1)([H])N1C(C([C@@]2(O)[C@H](C)C[C@H](OC)[C@@](O2)([H])[C@@H](OC)C[C@@H](C)[C@H](O)/C(C)=C/[C@H]3CC)=O)=O)O[C@H](/C(C)=C/[C@H]4C[C@@H](OC)[C@H](O)CC4)[C@H](C)[C@@H](O)CC3=O |
Biological Activity
| Description | L685818 is a specific immunophilin ligand that exhibits antifungal activity against Cryptococcus neoformans. In addition to its antifungal properties, L685818 demonstrates neuroregenerative effects by safeguarding dopaminergic neurons from toxicity associated with MPP+ and 6-OHDA. The compound effectively reduces the loss of tyrosine hydroxylase (TH) and promotes neuronal process regeneration, making it a valuable tool for research in neurodegenerative disease models and fungal infections. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
