Product Data Sheet
Itraconazole-d9
Catalog No. A28202
Itraconazole-d9 is a deuterium-labeled derivative of itraconazole, a triazole antifungal agent known for its function as a potent inhibitor of the Hedgehog (Hh) signaling pathway, with an IC50 of approximately 800 nM. This compound effectively inhibits lanosterol 14α-demethylase, a cytochrome P450 enzyme, disrupting the conversion of lanosterol to ergosterol. Itraconazole-d9 exhibits notable anticancer and antiangiogenic properties, making it suitable for research in cancer biology and related therapeutic applications. Additionally, it serves as an oxysterol-binding protein (OSBP) inhibitor, highlighting its versatility in biochemical research.
Chemical Information
| Catalog Num | A28202 |
|---|---|
| M. Wt | 714.69 |
| Formula | C35H29D9Cl2N8O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1309272-50-1 |
| Synonyms | R51211-d9 |
| SMILES | O=C(N(N=C1)C(C([2H])([2H])[2H])([2H])C([2H])([2H])C([2H])([2H])[2H])N1C(C=C2)=CC=C2N(CC3)CCN3C(C=C4)=CC=C4OC[C@@H](CO5)O[C@]5(C6=C(C=C(C=C6)Cl)Cl)CN7C=NC=N7 |
Biological Activity
| Description | Itraconazole-d9 is a deuterium-labeled derivative of itraconazole, a triazole antifungal agent known for its function as a potent inhibitor of the Hedgehog (Hh) signaling pathway, with an IC50 of approximately 800 nM. This compound effectively inhibits lanosterol 14α-demethylase, a cytochrome P450 enzyme, disrupting the conversion of lanosterol to ergosterol. Itraconazole-d9 exhibits notable anticancer and antiangiogenic properties, making it suitable for research in cancer biology and related therapeutic applications. Additionally, it serves as an oxysterol-binding protein (OSBP) inhibitor, highlighting its versatility in biochemical research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
