Product Data Sheet
Itraconazole-d5
Catalog No. A28242
Itraconazole-d5 is a deuterium-labeled form of Itraconazole, a triazole antifungal agent that functions primarily as a Hedgehog (Hh) signaling pathway antagonist with an IC50 of approximately 800 nM. This compound effectively inhibits lanosterol 14α-demethylase, a cytochrome P450 enzyme, blocking the conversion of lanosterol to ergosterol. Itraconazole-d5 is utilized in research applications investigating antifungal mechanisms, anticancer effects, and antiangiogenic properties.
Chemical Information
| Catalog Num | A28242 |
|---|---|
| M. Wt | 710.66 |
| Formula | C35H33D5Cl2N8O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1217510-38-7 |
| Synonyms | R51211-d5 |
| SMILES | ClC1=C(C=CC(Cl)=C1)[C@@]2(O[C@@H](COC3=CC=C(N4CCN(C5=CC=C(N(C=NN6C(C)C([2H])([2H])C([2H])([2H])[2H])C6=O)C=C5)CC4)C=C3)CO2)CN7C=NC=N7 |
Biological Activity
| Description | Itraconazole-d5 is a deuterium-labeled form of Itraconazole, a triazole antifungal agent that functions primarily as a Hedgehog (Hh) signaling pathway antagonist with an IC50 of approximately 800 nM. This compound effectively inhibits lanosterol 14α-demethylase, a cytochrome P450 enzyme, blocking the conversion of lanosterol to ergosterol. Itraconazole-d5 is utilized in research applications investigating antifungal mechanisms, anticancer effects, and antiangiogenic properties. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
