Product Data Sheet
iKIX1
Catalog No. A28251
iKIX1 is an antifungal agent that targets the KIX domain of the mediator subunit CgGal11A, interrupting its interaction with the activation domain of CgPdr1. This compound effectively resensitizes drug-resistant Candida glabrata to azole antifungals in vitro, with inhibition constants IC50 and Ki values of 190.2 μM and 18 μM, respectively. iKIX1 is utilized in research focused on understanding multidrug resistance mechanisms and addressing C. glabrata infections.
Chemical Information
| Catalog Num | A28251 |
|---|---|
| M. Wt | 303.17 |
| Formula | C10H8Cl2N4OS |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 656222-54-7 |
| Synonyms | |
| SMILES | O=C(NNC(NC1=CC=C(Cl)C(Cl)=C1)=S)CC#N |
Biological Activity
| Description | iKIX1 is an antifungal agent that targets the KIX domain of the mediator subunit CgGal11A, interrupting its interaction with the activation domain of CgPdr1. This compound effectively resensitizes drug-resistant Candida glabrata to azole antifungals in vitro, with inhibition constants IC50 and Ki values of 190.2 μM and 18 μM, respectively. iKIX1 is utilized in research focused on understanding multidrug resistance mechanisms and addressing C. glabrata infections. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
