Product Data Sheet
Itraconazole-d3
Catalog No. A28316
Itraconazole-d3 is a deuterium-labeled derivative of Itraconazole, a triazole antifungal that targets lanosterol 14α-demethylase, a cytochrome P450 enzyme, with an IC50 of approximately 800 nM. This compound acts as a potent antagonist of the Hedgehog (Hh) signaling pathway, and exhibits notable anticancer and antiangiogenic properties. Additionally, Itraconazole-d3 functions as an oxysterol-binding protein (OSBP) inhibitor, making it a valuable tool for studying fungal infections, cancer biology, and metabolic pathways in research settings.
Chemical Information
| Catalog Num | A28316 |
|---|---|
| M. Wt | 708.65 |
| Formula | C35H35D3Cl2N8O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1217512-35-0 |
| Synonyms | R51211-d3 |
| SMILES | O=C(N(N=C1)C(C([2H])([2H])[2H])CC)N1C(C=C2)=CC=C2N(CC3)CCN3C(C=C4)=CC=C4OC[C@@H](CO5)O[C@]5(C6=C(C=C(C=C6)Cl)Cl)CN7C=NC=N7 |
Biological Activity
| Description | Itraconazole-d3 is a deuterium-labeled derivative of Itraconazole, a triazole antifungal that targets lanosterol 14α-demethylase, a cytochrome P450 enzyme, with an IC50 of approximately 800 nM. This compound acts as a potent antagonist of the Hedgehog (Hh) signaling pathway, and exhibits notable anticancer and antiangiogenic properties. Additionally, Itraconazole-d3 functions as an oxysterol-binding protein (OSBP) inhibitor, making it a valuable tool for studying fungal infections, cancer biology, and metabolic pathways in research settings. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
