Product Data Sheet
Pentamidine-d4 dihydrochloride
Catalog No. A28319
Pentamidine-d4 dihydrochloride is a deuterium-labeled derivative of Pentamidine dihydrochloride, known for its role as an antimicrobial agent. This compound targets DNA biosynthesis and exhibits inhibitory effects on Leishmania infantum with an IC50 of 2.5 μM. Additionally, it acts as a potent and selective inhibitor of protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL). Pentamidine-d4 dihydrochloride holds therapeutic potential for conditions such as Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia, while also demonstrating antitumor and antibacterial activities.
Chemical Information
| Catalog Num | A28319 |
|---|---|
| M. Wt | 417.37 |
| Formula | C19H22D4Cl2N4O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1276197-32-0 |
| Synonyms | MP-601205-d4(dihydrochloride) |
| SMILES | N=C(C1=CC=C(C=C1)OC([2H])([2H])CCCC([2H])([2H])OC2=CC=C(C=C2)C(N)=N)N.Cl.Cl |
Biological Activity
| Description | Pentamidine-d4 dihydrochloride is a deuterium-labeled derivative of Pentamidine dihydrochloride, known for its role as an antimicrobial agent. This compound targets DNA biosynthesis and exhibits inhibitory effects on Leishmania infantum with an IC50 of 2.5 μM. Additionally, it acts as a potent and selective inhibitor of protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL). Pentamidine-d4 dihydrochloride holds therapeutic potential for conditions such as Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia, while also demonstrating antitumor and antibacterial activities. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
