Product Data Sheet
Thifluzamide
Catalog No. A28403
Thifluzamide is a potent antifungal agent that targets the ubiquinone-binding site of mitochondrial complex II, effectively inhibiting fungal respiration. This compound demonstrates significant activity against Basidiomycota pathogens, including genera such as Rhizoctonia, Ustilago, and Puccinia, making it valuable in studies related to wheat sharp eyespot. Additionally, Thifluzamide plays a dual role in lipid metabolism regulation by decreasing fatty acid synthase activity and enhancing carnitine palmitoyltransferase-I activity, leading to reduced cholesterol and triglyceride levels. However, caution is advised due to its potential hepatotoxic effects observed in zebrafish models and the risk of developmental toxicity.
Chemical Information
| Catalog Num | A28403 |
|---|---|
| M. Wt | 528.06 |
| Formula | C13H6Br2F6N2O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 130000-40-7 |
| Synonyms | |
| SMILES | O=C(C1=C(C(F)(F)F)N=C(C)S1)NC2=C(Br)C=C(OC(F)(F)F)C=C2Br |
Biological Activity
| Description | Thifluzamide is a potent antifungal agent that targets the ubiquinone-binding site of mitochondrial complex II, effectively inhibiting fungal respiration. This compound demonstrates significant activity against Basidiomycota pathogens, including genera such as Rhizoctonia, Ustilago, and Puccinia, making it valuable in studies related to wheat sharp eyespot. Additionally, Thifluzamide plays a dual role in lipid metabolism regulation by decreasing fatty acid synthase activity and enhancing carnitine palmitoyltransferase-I activity, leading to reduced cholesterol and triglyceride levels. However, caution is advised due to its potential hepatotoxic effects observed in zebrafish models and the risk of developmental toxicity. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
