Product Data Sheet
PC945
Catalog No. A28519
PC945 is a potent antifungal triazole that targets the sterol 14α-demethylase enzymes CYP51A and CYP51B in Aspergillus fumigatus, demonstrating strong inhibitory activity with IC50 values of 0.23 μM and 0.22 μM, respectively. This compound exhibits efficacy against a wide variety of both azole-susceptible and azole-resistant strains of A. fumigatus. PC945 is of significant interest in antifungal research and offers potential applications in the treatment of invasive fungal infections.
Chemical Information
| Catalog Num | A28519 |
|---|---|
| M. Wt | 682.73 |
| Formula | C38H37F3N6O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1931946-73-4 |
| Synonyms | |
| SMILES | O=C(NC1=CC=C(F)C=C1)C(C=C2)=CC=C2N3CCN(C4=CC=C(OC[C@@H]5CO[C@](C6=CC=C(F)C=C6F)(CN7N=CN=C7)C5)C(C)=C4)CC3 |
Biological Activity
| Description | PC945 is a potent antifungal triazole that targets the sterol 14α-demethylase enzymes CYP51A and CYP51B in Aspergillus fumigatus, demonstrating strong inhibitory activity with IC50 values of 0.23 μM and 0.22 μM, respectively. This compound exhibits efficacy against a wide variety of both azole-susceptible and azole-resistant strains of A. fumigatus. PC945 is of significant interest in antifungal research and offers potential applications in the treatment of invasive fungal infections. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
