Product Data Sheet
Pelitinib-d6
Catalog No. A28584
Pelitinib-d6 is a stable isotope-labeled variant of Pelitinib, an irreversible inhibitor of the epidermal growth factor receptor (EGFR). Pelitinib demonstrates potent biological activity with an IC50 of 38.5 nM against EGFR and also exhibits moderate inhibition of Src, MEK/ERK, and ErbB2 with IC50 values of 282, 800, and 1255 nM, respectively. This deuterium-labeled compound is valuable for studies requiring precise tracking of drug metabolism and pharmacokinetics, as well as kinetic and mechanistic investigations in cancer research.
Chemical Information
| Catalog Num | A28584 |
|---|---|
| M. Wt | 473.96 |
| Formula | C24H17D6ClFN5O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1325223-34-4 |
| Synonyms | |
| SMILES | CCOC(C(NC(/C=C/CN(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)=C1)=CC2=C1C(NC3=CC(Cl)=C(C=C3)F)=C(C#N)C=N2 |
Biological Activity
| Description | Pelitinib-d6 is a stable isotope-labeled variant of Pelitinib, an irreversible inhibitor of the epidermal growth factor receptor (EGFR). Pelitinib demonstrates potent biological activity with an IC50 of 38.5 nM against EGFR and also exhibits moderate inhibition of Src, MEK/ERK, and ErbB2 with IC50 values of 282, 800, and 1255 nM, respectively. This deuterium-labeled compound is valuable for studies requiring precise tracking of drug metabolism and pharmacokinetics, as well as kinetic and mechanistic investigations in cancer research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
