Product Data Sheet
Erlotinib-d4
Catalog No. A28598
Erlotinib-d4 is a deuterium-labeled analog of Erlotinib, a selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, with an IC50 of 2 nM for human EGFR. This compound effectively reduces EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM and is utilized in the treatment of non-small cell lung cancer. Additionally, Erlotinib-d4 serves as a valuable click chemistry reagent, featuring an alkyne group for performing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, facilitating various biochemical applications.
Chemical Information
| Catalog Num | A28598 |
|---|---|
| M. Wt | 397.46 |
| Formula | C22H19D4N3O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1130852-41-3 |
| Synonyms | CP-358774-d4; NSC 718781-d4; OSI-774-d4 |
| SMILES | COCCOC(C(OCCOC)=C1)=CC2=C1C(NC3=C([2H])C(C#C)=C([2H])C([2H])=C3[2H])=NC=N2 |
Biological Activity
| Description | Erlotinib-d4 is a deuterium-labeled analog of Erlotinib, a selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, with an IC50 of 2 nM for human EGFR. This compound effectively reduces EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM and is utilized in the treatment of non-small cell lung cancer. Additionally, Erlotinib-d4 serves as a valuable click chemistry reagent, featuring an alkyne group for performing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, facilitating various biochemical applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
