Product Data Sheet
(R)-Afatinib
Catalog No. A28607
(R)-Afatinib is a potent and irreversible dual specificity inhibitor targeting the ErbB family, specifically EGFR and HER2. With IC50 values of 0.5 nM, 0.4 nM, 10 nM, and 14 nM for EGFR wild type, EGFR L858R, EGFR L858R/T790M, and HER2, respectively, this compound exhibits significant biological activity against these receptors. (R)-Afatinib is utilized in research focused on esophageal squamous cell carcinoma, non-small cell lung cancer, and gastric cancer, providing essential insights into targeted therapies.
Chemical Information
| Catalog Num | A28607 |
|---|---|
| M. Wt | 485.94 |
| Formula | C24H25ClFN5O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 439081-17-1 |
| Synonyms | (R)-BIBW 2992 |
| SMILES | CN(C)C/C=C/C(NC1=CC(C(NC2=CC(Cl)=C(C=C2)F)=NC=N3)=C3C=C1O[C@@H]4CCOC4)=O |
Biological Activity
| Description | (R)-Afatinib is a potent and irreversible dual specificity inhibitor targeting the ErbB family, specifically EGFR and HER2. With IC50 values of 0.5 nM, 0.4 nM, 10 nM, and 14 nM for EGFR wild type, EGFR L858R, EGFR L858R/T790M, and HER2, respectively, this compound exhibits significant biological activity against these receptors. (R)-Afatinib is utilized in research focused on esophageal squamous cell carcinoma, non-small cell lung cancer, and gastric cancer, providing essential insights into targeted therapies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
