Product Data Sheet
EGFR-IN-166
Catalog No. A28635
EGFR-IN-166 is a selective inhibitor of the epidermal growth factor receptor (EGFR). This compound demonstrates potent anticancer activity, exhibiting IC50 values of 69.63 μM and 22.84 μM against MCF-7 and MDA-MB-231 breast cancer cell lines, respectively. In addition to its cytotoxic effects, EGFR-IN-166 significantly reduces cell migration and decreases EGFR expression. This reagent is valuable for research in breast cancer therapies and mechanisms of EGFR signaling.
Chemical Information
| Catalog Num | A28635 |
|---|---|
| M. Wt | 349.41 |
| Formula | C19H15N3O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 503443-98-9 |
| Synonyms | |
| SMILES | O=C1CN(C2=CC=CC=C2)/C(S1)=C3C(C)=NN(C4=CC=CC=C4)C/3=O |
Biological Activity
| Description | EGFR-IN-166 is a selective inhibitor of the epidermal growth factor receptor (EGFR). This compound demonstrates potent anticancer activity, exhibiting IC50 values of 69.63 μM and 22.84 μM against MCF-7 and MDA-MB-231 breast cancer cell lines, respectively. In addition to its cytotoxic effects, EGFR-IN-166 significantly reduces cell migration and decreases EGFR expression. This reagent is valuable for research in breast cancer therapies and mechanisms of EGFR signaling. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
