Product Data Sheet
Tyrphostin AG213
Catalog No. A28648
Tyrphostin AG213 is a selective inhibitor of the epidermal growth factor receptor (EGFR) with an IC50 of 0.85 μM, targeting its protein tyrosine kinase activity. In addition to its primary function, Tyrphostin AG213 also inhibits tyrosine kinase activity with an IC50 of 2.4 μM and topoisomerase II, exhibiting an IC100 of 50 μM. This compound has been shown to induce non-apoptotic programmed cell death in tumor cells, making it a valuable tool for cancer research and potential therapeutic applications.
Chemical Information
| Catalog Num | A28648 |
|---|---|
| M. Wt | 220.25 |
| Formula | C10H8N2O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 122520-86-9 |
| Synonyms | AG213 |
| SMILES | S=C(N)/C(C#N)=C/C1=CC=C(O)C(O)=C1.[(E)] |
Biological Activity
| Description | Tyrphostin AG213 is a selective inhibitor of the epidermal growth factor receptor (EGFR) with an IC50 of 0.85 μM, targeting its protein tyrosine kinase activity. In addition to its primary function, Tyrphostin AG213 also inhibits tyrosine kinase activity with an IC50 of 2.4 μM and topoisomerase II, exhibiting an IC100 of 50 μM. This compound has been shown to induce non-apoptotic programmed cell death in tumor cells, making it a valuable tool for cancer research and potential therapeutic applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
