Product Data Sheet
EG31
Catalog No. A28650
EG31 is a potent inhibitor of the epidermal growth factor receptor (EGFR), exhibiting strong antiproliferative effects on triple-negative breast cancer (TNBC) cells, with GI50 values of 498.90 nM for MDA-MB-231 and 740.73 nM for Hs578T cell lines. It effectively induces apoptosis by disrupting the EGFR signaling pathway. Additionally, EG31 retains its efficacy against 5-fluorouracil (5-FU)-resistant TNBC cells, demonstrating a GI50 of 519.5 nM. This compound is valuable for researching mechanisms of resistance in TNBC.
Chemical Information
| Catalog Num | A28650 |
|---|---|
| M. Wt | 671.25 |
| Formula | C30H13Br2N3O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 360760-58-3 |
| Synonyms | |
| SMILES | O=C1OC(C2=CC(N3C(C4=C(C3=O)C=CC=C4)=O)=CC(C5=NC6=C(C(O5)=O)C=C(C=C6)Br)=C2)=NC7=CC=C(C=C17)Br |
Biological Activity
| Description | EG31 is a potent inhibitor of the epidermal growth factor receptor (EGFR), exhibiting strong antiproliferative effects on triple-negative breast cancer (TNBC) cells, with GI50 values of 498.90 nM for MDA-MB-231 and 740.73 nM for Hs578T cell lines. It effectively induces apoptosis by disrupting the EGFR signaling pathway. Additionally, EG31 retains its efficacy against 5-fluorouracil (5-FU)-resistant TNBC cells, demonstrating a GI50 of 519.5 nM. This compound is valuable for researching mechanisms of resistance in TNBC. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
