Product Data Sheet
EGFR-IN-201
Catalog No. A28653
EGFR-IN-201 is a potent inhibitor of the epidermal growth factor receptor (EGFR), exhibiting an IC50 of 0.091 μM against wild-type EGFR. It demonstrates activity against mutant EGFR variants, with IC50 values of 0.147 μM for EGFRT790M, 0.221 μM for EGFRL858R, and 0.703 μM for EGFRC797S. Inhibition of downstream signaling pathways is evidenced by its IC50 values of 0.225 μg/mL for AKT1 and 0.705 μg/mL for ERK1. EGFR-IN-201 has been shown to induce G0/G1 cell cycle arrest, apoptosis, and low-level necrosis in cancer cells, making it a valuable tool for research in various cancer types, including colon cancer.
Chemical Information
| Catalog Num | A28653 |
|---|---|
| M. Wt | 340.40 |
| Formula | C17H16N4O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3103654-99-2 |
| Synonyms | |
| SMILES | COC1=CC=C(/C=C2C(N/C(S/2)=N\N=C(C)\C3=CC=CN3)=O)C=C1 |
Biological Activity
| Description | EGFR-IN-201 is a potent inhibitor of the epidermal growth factor receptor (EGFR), exhibiting an IC50 of 0.091 μM against wild-type EGFR. It demonstrates activity against mutant EGFR variants, with IC50 values of 0.147 μM for EGFRT790M, 0.221 μM for EGFRL858R, and 0.703 μM for EGFRC797S. Inhibition of downstream signaling pathways is evidenced by its IC50 values of 0.225 μg/mL for AKT1 and 0.705 μg/mL for ERK1. EGFR-IN-201 has been shown to induce G0/G1 cell cycle arrest, apoptosis, and low-level necrosis in cancer cells, making it a valuable tool for research in various cancer types, including colon cancer. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
