Product Data Sheet
EGFR-IN-101
Catalog No. A28658
EGFR-IN-101 is a selective inhibitor of the epidermal growth factor receptor (EGFR). This compound demonstrates potent inhibitory activity with IC50 values of 33.26 nM against the EGFRL858R/T790M/C797S mutation and 106.4 nM in Ba/F3-EGFRL858R/T790M/C797S cells. EGFR-IN-101 is valuable for research applications focused on non-small cell lung cancer (NSCLC) and provides a framework for investigating resistance mechanisms and therapeutic strategies targeting EGFR mutations.
Chemical Information
| Catalog Num | A28658 |
|---|---|
| M. Wt | 625.81 |
| Formula | C35H47N9O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2982583-44-6 |
| Synonyms | |
| SMILES | CN1CCN(C2CCN(C3=CC(OC)=C(NC4=NC=CC(N5C=C(CN[C@@H](C)CO)C(C6=CC=CC=C6)=N5)=N4)C=C3C)CC2)CC1 |
Biological Activity
| Description | EGFR-IN-101 is a selective inhibitor of the epidermal growth factor receptor (EGFR). This compound demonstrates potent inhibitory activity with IC50 values of 33.26 nM against the EGFRL858R/T790M/C797S mutation and 106.4 nM in Ba/F3-EGFRL858R/T790M/C797S cells. EGFR-IN-101 is valuable for research applications focused on non-small cell lung cancer (NSCLC) and provides a framework for investigating resistance mechanisms and therapeutic strategies targeting EGFR mutations. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
