Product Data Sheet
EGFR/HER2/TS-IN-2
Catalog No. A28667
EGFR/HER2/TS-IN-2 is a potent inhibitor targeting the epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and thymidylate synthase (TS), demonstrating IC50 values of 0.173, 0.125, and 1.12 µM, respectively. This compound exhibits significant cytotoxic activity against MDA-MB-231 breast cancer cell lines, with an IC50 of 1.69 µM. It is a valuable tool for research focused on cancer therapy and the study of tumor biology related to EGFR and HER2 signaling pathways.
Chemical Information
| Catalog Num | A28667 |
|---|---|
| M. Wt | 511.62 |
| Formula | C26H21N7OS2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2444364-04-7 |
| Synonyms | |
| SMILES | N#CC1=C(N2N=C(C)C=C2C)N=C(SCC(NC3=NC4=C(S3)C=C(C)C=C4)=O)N=C1C5=CC=CC=C5 |
Biological Activity
| Description | EGFR/HER2/TS-IN-2 is a potent inhibitor targeting the epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and thymidylate synthase (TS), demonstrating IC50 values of 0.173, 0.125, and 1.12 µM, respectively. This compound exhibits significant cytotoxic activity against MDA-MB-231 breast cancer cell lines, with an IC50 of 1.69 µM. It is a valuable tool for research focused on cancer therapy and the study of tumor biology related to EGFR and HER2 signaling pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
