Product Data Sheet
EGFR-IN-177
Catalog No. A28669
EGFR-IN-177 is a highly selective inhibitor of the epidermal growth factor receptor (EGFR), exhibiting IC50 values of 0.32 nM against the EGFR L858R mutation and 0.67 nM against EGFR D746-750, among others. This compound effectively inhibits lung cancer cell proliferation and the phosphorylation of EGFR, demonstrating significant potential for therapeutic applications in non-small cell lung cancer research. EGFR-IN-177 is a valuable tool for exploring mechanisms of resistance and sensitivity in targeted cancer therapies.
Chemical Information
| Catalog Num | A28669 |
|---|---|
| M. Wt | 520.63 |
| Formula | C27H36N8O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3062177-59-4 |
| Synonyms | |
| SMILES | OC[C@@H](N1C2=C(/C=C/C(C3=CC(C4=C(N(N=C4C)C)O[C@H](CN(C2)C)C)=N5)=NNC3=C5C)C(OCC)=N1)C |
Biological Activity
| Description | EGFR-IN-177 is a highly selective inhibitor of the epidermal growth factor receptor (EGFR), exhibiting IC50 values of 0.32 nM against the EGFR L858R mutation and 0.67 nM against EGFR D746-750, among others. This compound effectively inhibits lung cancer cell proliferation and the phosphorylation of EGFR, demonstrating significant potential for therapeutic applications in non-small cell lung cancer research. EGFR-IN-177 is a valuable tool for exploring mechanisms of resistance and sensitivity in targeted cancer therapies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
