Product Data Sheet
EGFR-IN-189
Catalog No. A28733
EGFR-IN-189 is a selective covalent inhibitor of the epidermal growth factor receptor (EGFR), with an IC50 value of 200 nM. This compound effectively targets the C797S mutant form of EGFR, demonstrating potent inhibition of cancer cell proliferation. Furthermore, EGFR-IN-189 disrupts EGFR phosphorylation and subsequently inhibits ERK1/2 phosphorylation, making it a valuable tool for research applications in non-small cell lung cancer.
Chemical Information
| Catalog Num | A28733 |
|---|---|
| M. Wt | 438.52 |
| Formula | C26H26N6O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3037398-18-5 |
| Synonyms | |
| SMILES | O=C(C=C1C#C)N(C2=CC=CC=C2)C3=C1C=NC(NC4=CC=C(N(C)CCN(C)C)C=C4)=N3 |
Biological Activity
| Description | EGFR-IN-189 is a selective covalent inhibitor of the epidermal growth factor receptor (EGFR), with an IC50 value of 200 nM. This compound effectively targets the C797S mutant form of EGFR, demonstrating potent inhibition of cancer cell proliferation. Furthermore, EGFR-IN-189 disrupts EGFR phosphorylation and subsequently inhibits ERK1/2 phosphorylation, making it a valuable tool for research applications in non-small cell lung cancer. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
