Product Data Sheet
BIEGi-1
Catalog No. A28740
BIEGi-1 is a selective inhibitor of the epidermal growth factor receptor (EGFR), primarily targeting the inhibition of EGFR-Rheb interactions within cells. It significantly suppresses EGFR kinase activity, as evidenced by reduced levels of p-Y1068-EGFR, and also impedes mTORC1 activation by lowering p-T389-S6K1 levels in EGFR-mutant cell lines. BIEGi-1 demonstrates pronounced antiproliferative effects on EGFR-mutant PC9 and HCC827 cells, exhibiting IC50 values of 17 nM and 20 nM, respectively. This compound is a valuable tool for investigating cancers associated with EGFR mutations, notably non-small cell lung cancer (NSCLC).
Chemical Information
| Catalog Num | A28740 |
|---|---|
| M. Wt | 615.72 |
| Formula | C36H37N7O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1429497-30-2 |
| Synonyms | |
| SMILES | O=C1N(C2=CC(NC(/C=C/C)=O)=CC=C2)C3=NC(NC4=C(C=C(N5CCN(CC5)C)C=C4)OC)=NC=C3C=C1CC6=CC=CC=C6 |
Biological Activity
| Description | BIEGi-1 is a selective inhibitor of the epidermal growth factor receptor (EGFR), primarily targeting the inhibition of EGFR-Rheb interactions within cells. It significantly suppresses EGFR kinase activity, as evidenced by reduced levels of p-Y1068-EGFR, and also impedes mTORC1 activation by lowering p-T389-S6K1 levels in EGFR-mutant cell lines. BIEGi-1 demonstrates pronounced antiproliferative effects on EGFR-mutant PC9 and HCC827 cells, exhibiting IC50 values of 17 nM and 20 nM, respectively. This compound is a valuable tool for investigating cancers associated with EGFR mutations, notably non-small cell lung cancer (NSCLC). |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
