Product Data Sheet
EGFR ligand-2
Catalog No. A28745
EGFR ligand-2 (compound C4) is a covalent inhibitor targeting the epidermal growth factor receptor (EGFR), exhibiting IC50 values of 21 nM for the EGFRL858R mutant and 48 nM for the EGFRL858R/T790M double mutant. This compound is useful in studying EGFR mutations associated with various cancers and can be utilized in the synthesis of PROTACs for targeted protein degradation research applications.
Chemical Information
| Catalog Num | A28745 |
|---|---|
| M. Wt | 537.66 |
| Formula | C30H35N9O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2737283-20-2 |
| Synonyms | |
| SMILES | C=CC(N1CCC[C@@H](C1)N2C(NC3=CC=CC=C3)=NC4=CN=C(N=C42)NC5=CC=C(C=C5)N6CCN(CC6)C)=O |
Biological Activity
| Description | EGFR ligand-2 (compound C4) is a covalent inhibitor targeting the epidermal growth factor receptor (EGFR), exhibiting IC50 values of 21 nM for the EGFRL858R mutant and 48 nM for the EGFRL858R/T790M double mutant. This compound is useful in studying EGFR mutations associated with various cancers and can be utilized in the synthesis of PROTACs for targeted protein degradation research applications. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
