Product Data Sheet
BMS-599626 dihydrochloride
Catalog No. A28756
BMS-599626 dihydrochloride is a small molecule pan-HER inhibitor that targets the human epidermal growth factor receptor family, specifically inhibiting HER1 (IC50=20 nmol/L) and HER2 (IC50=30 nmol/L) kinase activities. This compound functions by competing with ATP for binding to these receptors, thereby blocking their kinase activity and downstream signaling pathways through the inhibition of heterodimer formation between HER1 and HER2. BMS-599626 dihydrochloride serves as a valuable tool for investigating the antitumor effects in various tumor models overexpressing HER1 and HER2.
Chemical Information
| Catalog Num | A28756 |
|---|---|
| M. Wt | 603.48 |
| Formula | C27H29Cl2FN8O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1781932-33-9 |
| Synonyms | |
| SMILES | FC1=CC(CN2N=CC3=C2C=CC(NC4=NC=NN5C4=C(C(NC(OC[C@@H]6COCCN6)=O)=C5)C)=C3)=CC=C1.Cl.Cl |
Biological Activity
| Description | BMS-599626 dihydrochloride is a small molecule pan-HER inhibitor that targets the human epidermal growth factor receptor family, specifically inhibiting HER1 (IC50=20 nmol/L) and HER2 (IC50=30 nmol/L) kinase activities. This compound functions by competing with ATP for binding to these receptors, thereby blocking their kinase activity and downstream signaling pathways through the inhibition of heterodimer formation between HER1 and HER2. BMS-599626 dihydrochloride serves as a valuable tool for investigating the antitumor effects in various tumor models overexpressing HER1 and HER2. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
