Product Data Sheet
EGFR-IN-139
Catalog No. A28757
EGFR-IN-139 is a potent inhibitor of the epidermal growth factor receptor (EGFR) with IC50 values of 12.88 nM for wild type, 10.84 nM for L858R/T790M, and 42.68 nM for L858R/T790M/C797S mutants. This compound exhibits significant anticancer activity in A549 and H1975 cell lines, demonstrating strong selectivity for cancer cells that overexpress EGFR. EGFR-IN-139 is particularly relevant for research focused on nonsmall cell lung cancer (NSCLC).
Chemical Information
| Catalog Num | A28757 |
|---|---|
| M. Wt | 476.95 |
| Formula | C27H25ClN2O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1574321-31-5 |
| Synonyms | |
| SMILES | O=C(C1=CC=C2OCCOC2=C1)C(O3)=CC4=C3C(C)=NC=C4CN5CC6=C(C=CC=C6)CC5.Cl |
Biological Activity
| Description | EGFR-IN-139 is a potent inhibitor of the epidermal growth factor receptor (EGFR) with IC50 values of 12.88 nM for wild type, 10.84 nM for L858R/T790M, and 42.68 nM for L858R/T790M/C797S mutants. This compound exhibits significant anticancer activity in A549 and H1975 cell lines, demonstrating strong selectivity for cancer cells that overexpress EGFR. EGFR-IN-139 is particularly relevant for research focused on nonsmall cell lung cancer (NSCLC). |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
