Product Data Sheet
PROTAC EGFR degrader 13
Catalog No. A28760
PROTAC EGFR Degrader 13 is a targeted protein degradation compound that selectively degrades the epidermal growth factor receptor (EGFR). This degrader exhibits potent antiproliferative activity with an IC50 of 15.6 nM against Ba/F3 cells harboring the EGFR T790M-L858R-C797S mutations, demonstrating its effectiveness in EGFR-related cancer research. This reagent is suitable for investigating the underlying mechanisms of EGFR-driven malignancies and developing therapeutic strategies focused on targeted degradation pathways.
Chemical Information
| Catalog Num | A28760 |
|---|---|
| M. Wt | 1004.91 |
| Formula | C49H55BrN11O6P |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2861227-35-0 |
| Synonyms | |
| SMILES | O=C1C2=CC=C(N3CCN(CC4CCN(CC4)C5=C(C6=CN(C)N=C6)C=C(NC7=NC=C(C(NC8=CC=C(C9CC9)C=C8P(C)(C)=O)=N7)Br)C(OC)=C5)CC3)C=C2C(N1C%10C(NC(CC%10)=O)=O)=O |
Biological Activity
| Description | PROTAC EGFR Degrader 13 is a targeted protein degradation compound that selectively degrades the epidermal growth factor receptor (EGFR). This degrader exhibits potent antiproliferative activity with an IC50 of 15.6 nM against Ba/F3 cells harboring the EGFR T790M-L858R-C797S mutations, demonstrating its effectiveness in EGFR-related cancer research. This reagent is suitable for investigating the underlying mechanisms of EGFR-driven malignancies and developing therapeutic strategies focused on targeted degradation pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
