Product Data Sheet
EGFR-IN-167
Catalog No. A28776
EGFR-IN-167 is a selective inhibitor of the epidermal growth factor receptor (EGFR), exhibiting an IC50 of 0.19 nM. This compound demonstrates high potency against various EGFR mutants, with IC50 values of 0.109 nM for EGFR (L858R), 0.75 nM for EGFR (C797S), and <0.05 nM for EGFR (del19). EGFR-IN-167 covalently binds to the catalytically conserved lysine residue in EGFR within live mammalian cells, effectively inhibiting EGFR autophosphorylation and showing significant anti-proliferative activity. This reagent is valuable for research in non-small-cell lung carcinomas (NSCLC), glioblastoma, and other solid tumors.
Chemical Information
| Catalog Num | A28776 |
|---|---|
| M. Wt | 467.47 |
| Formula | C20H22FN3O7S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3052761-67-5 |
| Synonyms | |
| SMILES | O=S(OC1=CC=CC(NC2=C3C=C(OCCOC)C(OCCOC)=CC3=NC=N2)=C1)(F)=O |
Biological Activity
| Description | EGFR-IN-167 is a selective inhibitor of the epidermal growth factor receptor (EGFR), exhibiting an IC50 of 0.19 nM. This compound demonstrates high potency against various EGFR mutants, with IC50 values of 0.109 nM for EGFR (L858R), 0.75 nM for EGFR (C797S), and <0.05 nM for EGFR (del19). EGFR-IN-167 covalently binds to the catalytically conserved lysine residue in EGFR within live mammalian cells, effectively inhibiting EGFR autophosphorylation and showing significant anti-proliferative activity. This reagent is valuable for research in non-small-cell lung carcinomas (NSCLC), glioblastoma, and other solid tumors. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
