Product Data Sheet
EGFR-IN-87
Catalog No. A28785
EGFR-IN-87 is an EGFR tyrosine kinase inhibitor that demonstrates potent inhibition with IC50 values of 3.1 nM, 1.3 nM, and 7.1 nM for EGFR_d746-750, EGFR_L858R/T790, and wild-type EGFR in A431 cells, respectively. This compound is valuable for investigating EGFR-related signaling pathways and is applicable in cancer research, particularly in the context of targeted therapies for tumors expressing mutated forms of the receptor.
Chemical Information
| Catalog Num | A28785 |
|---|---|
| M. Wt | 499.61 |
| Formula | C28H33N7O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1835666-87-9 |
| Synonyms | |
| SMILES | O=C(NC1=CC(NC2=NC=CC(N3C=C(C)C4=C3C=CC=C4)=N2)=C(C=C1N(CCN(C)C)C)OC)C=C |
Biological Activity
| Description | EGFR-IN-87 is an EGFR tyrosine kinase inhibitor that demonstrates potent inhibition with IC50 values of 3.1 nM, 1.3 nM, and 7.1 nM for EGFR_d746-750, EGFR_L858R/T790, and wild-type EGFR in A431 cells, respectively. This compound is valuable for investigating EGFR-related signaling pathways and is applicable in cancer research, particularly in the context of targeted therapies for tumors expressing mutated forms of the receptor. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
