Product Data Sheet
EGFR mutant-IN-2
Catalog No. A28789
EGFR mutant-IN-2 (Compound D51) is a selective inhibitor targeting the EGFR mutant variants, specifically EGFRL858R/T790M/C797S and EGFRdel19/T790M/C797S, with IC50 values of 14 nM and 62 nM, respectively. This compound demonstrates significant antitumor activity alongside favorable pharmacokinetic properties and in vivo stability, making it a valuable tool for research in cancer therapeutics. Its ability to effectively inhibit challenging EGFR mutations underscores its potential application in studying resistance mechanisms and developing targeted treatments.
Chemical Information
| Catalog Num | A28789 |
|---|---|
| M. Wt | 556.60 |
| Formula | C27H27F3N6O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2770009-06-6 |
| Synonyms | |
| SMILES | FC(F)(F)C1=CN=C(NC2=CC(C=CN3CCN(C)C)=C3C=C2)N=C1C4=CN(S(CC)(=O)=O)C5=C4C=CC=C5 |
Biological Activity
| Description | EGFR mutant-IN-2 (Compound D51) is a selective inhibitor targeting the EGFR mutant variants, specifically EGFRL858R/T790M/C797S and EGFRdel19/T790M/C797S, with IC50 values of 14 nM and 62 nM, respectively. This compound demonstrates significant antitumor activity alongside favorable pharmacokinetic properties and in vivo stability, making it a valuable tool for research in cancer therapeutics. Its ability to effectively inhibit challenging EGFR mutations underscores its potential application in studying resistance mechanisms and developing targeted treatments. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
