Product Data Sheet
Erlotinib-d6 hydrochloride
Catalog No. A28790
Erlotinib-d6 hydrochloride is a deuterium-labeled inhibitor of the epidermal growth factor receptor (EGFR) kinase, demonstrating potent inhibition with an IC50 of 2 nM. This compound serves as a valuable tool in chemical research, particularly in the study of EGFR-related signaling pathways in cancer. Additionally, Erlotinib-d6 hydrochloride features an alkyne group, enabling its application in click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating the labeling and tracking of biomolecules containing azide groups.
Chemical Information
| Catalog Num | A28790 |
|---|---|
| M. Wt | 435.93 |
| Formula | C22H18D6ClN3O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1189953-78-3 |
| Synonyms | CP-358774-d6 hydrochloride; NSC 718781-d6 hydrochloride; OSI-774-d6 hydrochloride |
| SMILES | [2H]C([2H])([2H])OCCOC1=CC2=NC=NC(NC3=CC=CC(C#C)=C3)=C2C=C1OCCOC([2H])([2H])[2H].[H]Cl |
Biological Activity
| Description | Erlotinib-d6 hydrochloride is a deuterium-labeled inhibitor of the epidermal growth factor receptor (EGFR) kinase, demonstrating potent inhibition with an IC50 of 2 nM. This compound serves as a valuable tool in chemical research, particularly in the study of EGFR-related signaling pathways in cancer. Additionally, Erlotinib-d6 hydrochloride features an alkyne group, enabling its application in click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating the labeling and tracking of biomolecules containing azide groups. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
