Product Data Sheet
Gefitinib-d6
Catalog No. A28792
Gefitinib-d6 is the deuterated form of Gefitinib, a highly selective and orally bioavailable inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, with an IC50 of 33 nM. This compound effectively inhibits EGF-mediated tumor cell proliferation (IC50 of 54 nM) and prevents EGFR autophosphorylation in cancer cells. Additionally, Gefitinib can induce autophagy, further contributing to its antitumoral effects. Gefitinib-d6 is valuable for studies involving metabolic labeling and pharmacokinetics in cancer research.
Chemical Information
| Catalog Num | A28792 |
|---|---|
| M. Wt | 452.94 |
| Formula | C22H18D6ClFN4O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1228664-49-0 |
| Synonyms | ZD1839-d6 |
| SMILES | COC1=CC2=C(C=C1OC([2H])(C([2H])(C([2H])(N3CCOCC3)[2H])[2H])[2H])C(NC4=CC=C(C(Cl)=C4)F)=NC=N2 |
Biological Activity
| Description | Gefitinib-d6 is the deuterated form of Gefitinib, a highly selective and orally bioavailable inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, with an IC50 of 33 nM. This compound effectively inhibits EGF-mediated tumor cell proliferation (IC50 of 54 nM) and prevents EGFR autophosphorylation in cancer cells. Additionally, Gefitinib can induce autophagy, further contributing to its antitumoral effects. Gefitinib-d6 is valuable for studies involving metabolic labeling and pharmacokinetics in cancer research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
