Product Data Sheet
4-Methyl erlotinib
Catalog No. A28798
4-Methyl erlotinib is a potent and selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. This compound effectively disrupts EGF-mediated tumor cell proliferation by significantly lowering EGFR-specific tyrosine phosphorylation levels. In preclinical studies utilizing a mouse model of human tumor transplantation, 4-Methyl erlotinib exhibited notable and prolonged inhibition of EGFR phosphotyrosine levels, leading to substantial growth inhibition in EGFR-dependent human malignancies.
Chemical Information
| Catalog Num | A28798 |
|---|---|
| M. Wt | 407.46 |
| Formula | C23H25N3O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1346601-52-2 |
| Synonyms | |
| SMILES | C#CC1=CC(NC2=C3C=C(OCCOC)C(OCCOC)=CC3=NC=N2)=CC=C1C |
Biological Activity
| Description | 4-Methyl erlotinib is a potent and selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. This compound effectively disrupts EGF-mediated tumor cell proliferation by significantly lowering EGFR-specific tyrosine phosphorylation levels. In preclinical studies utilizing a mouse model of human tumor transplantation, 4-Methyl erlotinib exhibited notable and prolonged inhibition of EGFR phosphotyrosine levels, leading to substantial growth inhibition in EGFR-dependent human malignancies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
