Product Data Sheet
EGFR/HER2-IN-9
Catalog No. A28799
EGFR/HER2-IN-9 is a potent inhibitor of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2). It demonstrates inhibitory activity with IC50 values of 3.2 nM against EGFR, 8.3 nM against the EGFR T790M mutant, and 14 nM against HER2. This compound is applicable in research focused on targeted cancer therapies, particularly for tumors exhibiting dysregulated EGFR and HER2 signaling pathways.
Chemical Information
| Catalog Num | A28799 |
|---|---|
| M. Wt | 513.95 |
| Formula | C25H25ClFN5O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1637253-79-2 |
| Synonyms | |
| SMILES | COC(C(NC(/C=C/CN1C[C@@]2([H])[C@@](OCCO2)([H])C1)=O)=C3)=CC4=C3C(NC5=CC(Cl)=C(C=C5)F)=NC=N4 |
Biological Activity
| Description | EGFR/HER2-IN-9 is a potent inhibitor of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2). It demonstrates inhibitory activity with IC50 values of 3.2 nM against EGFR, 8.3 nM against the EGFR T790M mutant, and 14 nM against HER2. This compound is applicable in research focused on targeted cancer therapies, particularly for tumors exhibiting dysregulated EGFR and HER2 signaling pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
