Product Data Sheet
YS-67
Catalog No. A28803
YS-67 is a highly effective inhibitor of the epidermal growth factor receptor (EGFR), exhibiting an IC50 of 5.2 nM. This compound significantly reduces the phosphorylation of EGFR and AKT, indicating its potential to disrupt downstream signaling pathways. YS-67 demonstrates notable antiproliferative effects on human cancer cell lines, including A549, PC-9, and A431, with IC50 values of 4.1 μM, 0.5 μM, and 2.1 μM, respectively. This makes YS-67 a valuable reagent for research focused on therapeutic strategies targeting EGFR in various cancer models.
Chemical Information
| Catalog Num | A28803 |
|---|---|
| M. Wt | 522.64 |
| Formula | C32H34N4O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2761327-15-3 |
| Synonyms | |
| SMILES | COC1=C(OCCCN2CCOCC2)C=C3C(C(C4=CC=CC=C4N5CC)=C5C6=CC=CC=C6)=NC=NC3=C1 |
Biological Activity
| Description | YS-67 is a highly effective inhibitor of the epidermal growth factor receptor (EGFR), exhibiting an IC50 of 5.2 nM. This compound significantly reduces the phosphorylation of EGFR and AKT, indicating its potential to disrupt downstream signaling pathways. YS-67 demonstrates notable antiproliferative effects on human cancer cell lines, including A549, PC-9, and A431, with IC50 values of 4.1 μM, 0.5 μM, and 2.1 μM, respectively. This makes YS-67 a valuable reagent for research focused on therapeutic strategies targeting EGFR in various cancer models. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
