Product Data Sheet
GW583340 dihydrochloride
Catalog No. A28807
GW583340 dihydrochloride is a potent dual inhibitor of the epidermal growth factor receptor (EGFR) and ErbB2 tyrosine kinases, with IC50 values of 0.01 μM and 0.014 μM, respectively. This compound effectively reverses drug resistance mediated by ABCG2 and ABCB1 transporters, enhancing the efficacy of chemotherapeutic agents. GW583340 dihydrochloride demonstrates significant anti-cancer activity, making it a valuable tool for research in cancer biology and therapeutic development.
Chemical Information
| Catalog Num | A28807 |
|---|---|
| M. Wt | 671.03 |
| Formula | C28H27Cl3FN5O3S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1173023-85-2 |
| Synonyms | |
| SMILES | O=S(CCNCC1=NC(C2=CC3=C(NC4=CC=C(OCC5=CC=CC(F)=C5)C(Cl)=C4)N=CN=C3C=C2)=CS1)(C)=O.Cl.Cl |
Biological Activity
| Description | GW583340 dihydrochloride is a potent dual inhibitor of the epidermal growth factor receptor (EGFR) and ErbB2 tyrosine kinases, with IC50 values of 0.01 μM and 0.014 μM, respectively. This compound effectively reverses drug resistance mediated by ABCG2 and ABCB1 transporters, enhancing the efficacy of chemotherapeutic agents. GW583340 dihydrochloride demonstrates significant anti-cancer activity, making it a valuable tool for research in cancer biology and therapeutic development. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
