Product Data Sheet
DDC-01-163
Catalog No. A28813
DDC-01-163 is an allosteric PROTAC degrader that targets the epidermal growth factor receptor (EGFR) through the ubiquitin-proteasome system. It demonstrates selective inhibition of L858R/T790M mutant Ba/F3 cell proliferation and is effective against resistant variants, including L/T/C797S and L/T/L718Q EGFR mutations. DDC-01-163 exhibits enhanced anti-proliferative effects in combination with the ATP-site EGFR inhibitor Osimertinib, making it a valuable tool for studying non-small cell lung cancer.
Chemical Information
| Catalog Num | A28813 |
|---|---|
| M. Wt | 942.05 |
| Formula | C49H51N9O9S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2140806-84-2 |
| Synonyms | |
| SMILES | O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCCOCCOCCOCCN4CCN(CC4)C5=CC=C(C6=CC=C7C(C(N(C(C8=CC=CC=C8)C(NC9=NC=CS9)=O)C7)=O)=C6)C=N5)=CC=C3)=O)=O |
Biological Activity
| Description | DDC-01-163 is an allosteric PROTAC degrader that targets the epidermal growth factor receptor (EGFR) through the ubiquitin-proteasome system. It demonstrates selective inhibition of L858R/T790M mutant Ba/F3 cell proliferation and is effective against resistant variants, including L/T/C797S and L/T/L718Q EGFR mutations. DDC-01-163 exhibits enhanced anti-proliferative effects in combination with the ATP-site EGFR inhibitor Osimertinib, making it a valuable tool for studying non-small cell lung cancer. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
